Santini is an Italian surname. Notable people with the surname include:André Santini (1940–2026), French politician
Bob Santini, American basketball player
Brandon Santini, American blues harmonica player, singer and songwriter
Chay Santini, Puerto Rican fashion model and actress
Claudio Santini, Italian football player
Dalmazio Santini (1923–2001), Italian-born U.S. composer
Daniele Santini, Italian sprint canoeist
Didier Santini, French football player
Edna Santini, Brazilian rugby sevens player
Fortunato Santini (1777–1861), Italian priest, composer and music collector
Gabriel Santini, Italian footballer
Gabriele Santini (1886–1964), Italian conductor
Giovanni Sante Gaspero Santini (1787–1877), Italian astronomer and mathematician
Graziella Santini, Sammarinese athlete
Giuseppe Santini (1735–1796), Italian abbot and a mathematician
Inti Muñoz Santini, Mexican politician
Ivan Santini, Croatian footballer
Jacques Santini, French footballer
James David Santini (1937–2015), United States Representative from Nevada
Jan Santini Aichel (1677–1723), Czech baroque architect of Italian descent
Jorge Santini, Puerto Rican politician, former mayor of San Juan
Krševan Santini, Croatian football goalkeeper
Nadia Santini, Italian chef
Nilmaris Santini (1959–2006), Puerto Rican female judoka
Norma Santini, Venezuelan fencer
Rinaldo Santini (1914–2013), Italian Christian Democrat politician
Ruggiero Santini (1870–1958), Italian general
Steven Santini, American ice hockey defenseman
Seven Santini Brothers, founders of the eponymous moving and storage company
Wellentony Tafua Santini, Australian rugby league footballer
