Nardilysin is an enzyme that in humans is encoded by the gene NRDC. Nardilysin is a type of protease, which means it functions to cut the bonds between certain amino acids. More specifically, it’s an endopeptidase that cleaves bonds at the N-terminus of arginine residues connected to other basic amino acids. This activity also explains its alternative name, N-arginine dibasic convertase, hence its standard name.

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Nardilysin (EC 3.4.24.61) is an enzyme that in humans is encoded by the gene NRDC (formally NRD1). Nardilysin is a type of protease, which means it functions to cut the bonds between certain amino acids. More specifically, it’s an endopeptidase that cleaves bonds at the N-terminus of arginine residues connected to other basic amino acids. This activity also explains its alternative name, N-arginine dibasic convertase, hence its standard name.\n

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Interactions

Nardilysin has been shown to interact with Heparin-binding EGF-like growth factor.\n

Enzyme activity

Nardilysin is a type of enzyme also called N-arginine dibasic convertase or NRD-convertase. This enzyme catalyses the following chemical reaction:\n

Hydrolysis of polypeptides, preferably at -Xaa-Arg-Lys-, and less commonly at -Arg-Arg-Xaa-, in which Xaa is not Arg or Lys

References

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Interactions

Enzyme activity

References

Further reading

NRD1

Broadcast History