[{"_1":2,"_3":-5,"_4":-5},"loaderData",{"_5":6},"actionData","errors","components/artists/ArtistDetail",{"_7":8,"_9":10,"_11":12,"_13":14},"artist",{"_44":45,"_46":7,"_47":48,"_49":50},"language","nl","bio",{"_11":15},"similarArtists",[],{"_16":17,"_18":19,"_20":21,"_22":23,"_24":25,"_26":27,"_28":29,"_30":31},"summary","

The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.

","content","

The ANTH domain is a membrane binding domain that shows weak specificity for PtdIns(4,5)P2. It was found in AP180 (homologous to CALM) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.\n

Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y).\n

An ANTH domain is also found in HIP1 and HIP1R, and the PtdIns(4,5)P2 binding sequence is conserved.\n

\n\n

Human proteins containing this domain

HIP1; HIP1R; PICALM; SNAP91;\n

References

\n\n

External links

UMich Orientation of Proteins in Membranes protein/pdbid-1hfa - Calculated spatial position of ANTH domain of CALM protein in membrane

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Human proteins containing this domain

References

Further reading

External links

ANTH

Broadcast History